Jump to content

Search the Community

Showing results for tags 'medicine'.

  • Search By Tags

    Type tags separated by commas.
  • Search By Author

Content Type


Forums

  • Forum Introduction & Feedback
    • Site Announcements, Rules & New Member Intros
    • TechInferno Forum Feedback
  • Tech News & Reviews
    • News & Reviews
  • Notebook Discussion
    • General Notebook Discussions
    • Notebook OEM Subforums
    • What Notebook Best Fits My Needs?
    • Legacy Articles
  • Desktop & General Hardware
    • General Desktops Discussion
    • Desktop Hardware
    • Overclocking, Cooling & Build Logs
  • Software, Networking & Gaming
    • PC & Console Gaming
    • Video Driver Releases & Discussion
    • Networking
    • General Software Discussion
  • Everything Else
    • Off Topic
  • Legacy Section (Not Actively Supported)
    • DIY e-GPU Projects

Categories

  • SVL7 & Klem VBIOS Mods
    • AMD
    • Alienware M11x R3
    • Alienware M14x R2
    • Alienware M17x R4
    • Alienware M18x R1
    • Alienware M18x R2
    • Kepler VBIOS
    • Lenovo Y400-Y500
    • Lenovo Y410p-Y510p
    • Lenovo Y580-Y480
    • Legacy BIOS/VBIOS
    • Maxwell VBIOS
    • Sony Vaio SVS13 / SVS15 series
  • BAKED BIOS Mods
    • Clevo
  • Utilities

Find results in...

Find results that contain...


Date Created

  • Start

    End


Last Updated

  • Start

    End


Filter by number of...

Joined

  • Start

    End


Group


Steam


AIM


MSN


Website URL


Yahoo


Jabber


Skype


Location


Interests


Occupation

Found 1 result

  1. In the not so distant future, we will be tackling many diseases and cancers using the newest revolution in biotechnology that involves targeting very specific parts of DNA and then snipping it. One such technique that has taken the biotechnology world by storm is CRISPR which involves the use of a cas9 endonuclease and guide RNA. This complex is recruited to a target sequence and cas9 cuts the desired region that results in a double strand break. With this double stranded DNA break, it can be ligated back together with a method called Non-Homologous End-Joining (NHEJ) to introduce random mutations via insertions/deletions to knock out a specific gene. Another method of repair called Homology Directed Repair (HDR) involves using a repair template that has homology to the flanking region of the double stranded break which results in controlled gene editing allowing researchers to use it for gene knock-out, knock-in, tagging etc. There are other competing methods such as TALENs (Transcription Activator-Like Effector Nucleases) which a French biotechnology company called Cellectis is using to experiment for possible cancer treatment. As mentioned above, CRISPR uses guide RNA to direct DNA breaks where as TALENs employs the use of 18 repeats of 34 amino acids that vary at amino acids 12 and 13 which is the "Repeat Variable Diresidue" or RVD; RVD mediates the DNA binding specificity. (image credit: genecopeia) A pair of TALEN are targeted to opposite sides of a desired break site. Each TALEN is a chimeric protein with Fok I nuclease domain that results in a specific double stranded break. (image credit: genecopoeia) The use of this technology is detailed in article by Business Insider where an infant in the UK named Layla was born with leukemia that had failed to be treated using common cancer treatment modalities such as chemotherapy and bone marrow transplant. Doctors there knew about Cellectis's work with TALENs and reached out as a last ditch effort to save her. Cellectis accepted their request and began her therapy by targeting her T-cells using TALENs to stimulate her immune system to attack the cancer and the result was complete remission. While many people will be weary of the possible abuse of such technologies, they should set those fears aside because it is this type of technology that will one day lead to the precise targeting and elimination of many diseases including cancer. View full article
×
×
  • Create New...

Important Information

By using this site, you agree to our Terms of Use. We have placed cookies on your device to help make this website better. You can adjust your cookie settings, otherwise we'll assume you're okay to continue.