Just wanted throw in my experience as another data point. I just finished building my eGPU setup (specs below) and am experiencing the same ~20% success rate for getting to the boot screen. If I recall it worked well the first few boots but now not so much. I wish I had paid better attention to any changes during that time. My boot sequence goes - power everything down - connect thunderbolt - power up atx/egpu - power up macbook. However, like you guys, when I hold down the power button on the macbook I get nothing 80% of the time. The fans on the GPU spin up but no boot screen. When it does boot it's running fine, I've had several multi hour sessions without crashes. Another random observation is that now when booting with or without the eGPU connected, the boot chime on the macbook is no longer happening (even on success boots). Setup: 2013 Macbook Pro Retina w/ GT 750m Akitio box, no riser Zotac GTX 970